Sci Rep. 2020 Jan 24;10(1):1155. doi: 10.1038/s41598-020-58184-3. Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Evaluation of Medication Effectiveness; 8 pages. The benefits of theophylline may be recognized at lower serum levels than previously recommended (a target range of 5–15 µg/mL). An evaluation of theophylline for idiopathic apnea of infancy. This site needs JavaScript to work properly. Results: nicotine, phenobarbital, phenytoin (Dilantin) can increase metabolism of theophylline causing a decrease in blood level Client Education Evaluation of Medication Effectiveness Blood level is maintained in therapeutic range. Toxic (unwanted) side effects. 19 infants admitted with a diagnosis of infantile apnea who were found to have periodic breathing were given oral theophylline to determine its effect. Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial. 2019 Aug 22;8(9):1283. doi: 10.3390/jcm8091283. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Theophylline concentrations are increased by cimetidine, however, famotidine, nizatidine, and ranitidine do not appear to interact. Please enable it to take advantage of the complete set of features! Note:…, Subgroup meta-analysis of adverse events…, Subgroup meta-analysis of adverse events in placebo-controlled trials ( A ) or active…, Funnel plot analysis of FEV1 ( A ), PEFR ( B ), symptom…, NLM 1989;83(22):1097-102. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. In another study, the bioavailability of the 600 mg theophylline (anhydrous) extended-release tablet was examined with morning and evening administration. Provide periodic follow-up, including blood tests, to monitor serum theophylline levels. Auckland, New Zealand: Global Asthma Network; 2014. Subgroup meta-analysis of symptom scores following intravenous theophylline by age group. Theophylline in the past and present. homework. Global Asthma Network . and improve the patient compliance. Nausea, vomiting and loss of appetite are the most common signs of mild toxicity. Promise and limitations. [Clinico-laboratory evaluation a new sustained-release preparation of anhydrous theophylline]. eCollection 2018 Aug 20. Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a … Notes: Studies…, Subgroup meta-analysis of FEV1 following intravenous theophylline by blinding of study participants. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Twenty patients (12 male, 8 female) affected by bronchial asthma (mean age 45 years) or chronic obstructive lung disease (mean … Finer NN, Peters KL, Duffley LM, Coward JH. PRISMA flow diagram. Double-blind, randomised, controlled trial assessing controller medications in asthma. Would you like email updates of new search results? We planned a priori subgroup analyses by time post-medication, concomitant medication, control type, and age. Notes: A total of 193 records were identified through database…, Assessment of study quality. NUR 2407. homework. Provide follow-ups. Learn who it’s for, how it works, its side effects, warnings, and more. Chest. Rasmussen College, Land O' Lakes. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, … Find user ratings and reviews for theophylline oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction May ↓ the beneficial beta 1 -cardiovascular effects of dopamine or dobutamine . Closer examination of the data revealed that the medications given in addition to theophylline or control significantly changed the effectiveness of theophylline (subgroup difference: p … Theophylline is considered a component of a treatment plan. 2004 Mar;190(3):737-44. doi: 10.1016/j.ajog.2003.09.071. Despite its longevity in the practitioner's formulary, no detailed meta-analysis has been performed to determine the conditions, including concomitant medications, under which theophylline should be used for acute exacerbations of asthma. http://www.who.int/gard/publications/GARD_Manual/en/, https://www.drugs.com/condition/asthma.html, To T, Stanojevic S, Moores G, et al. [cited May 31, 2017]. The global asthma report 2014. Would you like email updates of new search results? Acute Med Surg. INTRODUCTION. Avoid excessive intake of coffee, tea, cocoa, cola beverages, and chocolate. Theophylline in asthma and COPD: changing perspectives and controversies. Kouzegaran S, Samimi P, Ahanchian H, Khoshkhui M, Behmanesh F. Open Access Maced J Med Sci. We aimed to quantify the usefulness and side effects of theophylline with or without ethylene diamine (aminophylline) in acute asthma, with particular emphasis on patient subgroups, such as children, adults, and concomitant medications. Theophylline was historically used as primary treatment for asthma but its use has become rare due to the availability and better tolerability of alternative treatments for asthma ... (increased theophylline clearance) Drug interactions . We searched PubMed, EMBASE, The Cochrane Library, ClinicalTrials.gov, and the WHO Clinical Trials Registry for randomized, controlled clinical trials. Sustained or severe CNS signs may indicate overdose or excessive use of this drug. Many drugs can affect theophylline. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach [Internet] WHO; [Accessed May 31, 2017]. Monitor and report signs of CNS toxicity, including tremor, anxiety, irritability, or other changes in mood or behavior. Available from: List of Asthma Medications (62 Compared) [Internet]. Increased clearance with ... Paloucek FP, Rodvold KA. doi: 10.1371/journal.pone.0153877. Notes: ( A ) Risk of bias graph. Long-term therapy with sustained-release theophylline. Given the low cost of theophylline, and its similar efficacy and rate of side effects compared with other drugs, we suggest that theophylline, when given with bronchodilators with or without steroids, is a cost-effective and safe choice for acute asthma exacerbations. Subgroup meta-analysis of adverse events in placebo-controlled trials (. Of these, 29 study arms included an active control, such as adrenaline, beta-2 agonists, or leukotriene receptor antagonists, and 23 study arms compared theophylline (with or without ethylene diamine) with placebo or no drug. Theophylline has been used for decades to treat both acute and chronic asthma. In this study the mean fed/fasted ratios for the one and one-half 400 mg tablets and the 600 mg tablet were about 112% and 104%, respectively. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Increased concentrations of intracellular cAMP may mediate most of the pharmacological effects of the drug. Ensure that diazepam is readily available to treat seizures. Report changes in pulmonary function to help document the effects of drug therapy in treating or preventing bronchoconstriction. Individual drug response. 1987;7(5):351-6. Twenty patients (12 male, 8 female) affected by bronchial asthma (mean age 45 years) or chronic obstructive lung disease (mean age 58 years) were given the drug. Smoking cigarettes or other tobacco products may markedly influence the effects of theophylline. Z Arztl Fortbild (Jena). This site needs JavaScript to work properly. In this study the effectiveness and safety of a new controlled-release theophylline formulation were evaluated. In this study the effectiveness and safety of a new controlled-release theophylline formulation were evaluated. Methylxanthine use for acute asthma in the emergency department in Japan: a multicenter observational study. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective … Note: Data…, Meta-analysis of symptom scores ( A ), admission rates ( B ), duration…, Subgroup meta-analysis of FEV1 following…, Subgroup meta-analysis of FEV1 following intravenous theophylline by background medication. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Subgroup meta-analysis of PEFR following intravenous theophylline by time post-infusion, as measured in liters (, Subgroup meta-analysis of heart rate (beats per minute) following intravenous theophylline by time after infusion (. 2006;73(4):449-56. doi: 10.1159/000090898. Quality of Life in Children with Asthma versus Healthy Children. -inhibit metabolism of theophylline, leading to increased risk of theophylline levels -used concurrently with phenytoin can inhibit effects of montelukast Zafirlukast: Evaluation of medication effectiveness Monitor heart rate and rhythm. Notes: Background medication…, Subgroup meta-analysis of symptom scores…, Subgroup meta-analysis of symptom scores following intravenous theophylline by age group. Theophylline is an oral medication used to treat asthma and other lung diseases. eCollection 2019 Jul. Serum theophylline concentrations and pulmonary function tests after administration of two sustained-release formulations containing theophylline in patients affected by chronic obstructive lung disease. + + + … Theophylline was not significantly different from other drugs in its effects on respiratory rate, forced vital capacity (FVC), peak expiratory flow rate, admission rate, use of rescue medication, oxygen saturation, or symptom score. COVID-19 is an emerging, rapidly evolving situation. Patients presenting with elevated theophylline concentrations and manifestations of toxicity may be categorized as being either overdose or iatrogenic toxic.  |  It is preferable not to smoke while you are taking this drug. 111 Serum drug level monitoring is needed with doses above 12 mg/kg or if side-effects occur. These contain theophylline-related substances that may increase your side effects. Commonly-used drugs that interact with theophylline; Benzodiazepines. It competitively inhibits phosphodiesterase, the enzyme that degrades cyclic 3',5'-adenosine mono phosphate (cAMP). Many other medications may also interact with theophylline, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Keywords: WHO . cimetidine (Tagamet), some fluoroquinolones, and caffeine can increase risk of toxicity. [Theophylline in the treatment of asthma: indications, use and side effects]. Subgroup meta-analysis of FEV1 following intravenous theophylline by blinding of study participants. If you take St. John's wort regularly, do not stop taking it without first asking your doctor. USA.gov. COPD Foundation. May ↓ the effectiveness of theophylline. They were studied at a mean age of 7.1 weeks (1-16.4 week). Many patients experience minor adverse effects of theophylline therapy, and for this reason the drug is usually only prescribed for the prevention of asthma attacks, after other anti-asthma drugs have failed. As a result of its pharmacological effects, Theophylline at serum concentrations within the 10-20 mcg/mL range modestly increases plasma glucose (from a mean of 88 mg% to 98 mg%), uric acid (from a mean of 4 mg/dL to 6 mg/dL), free fatty acids (from a mean of 451 ⛤Eq/L to 800 ⛤Eq/L, total cholesterol (from a mean of 140 vs 160 mg/dL), HDL (from a mean of 36 to 50 mg/dL), HDL/LDL ratio (from a mean of 0.5 to 0.7), and urinary free cortisol excretion … 2018 Aug 16;6(8):1413-1418. doi: 10.3889/oamjms.2018.287.  |  Expert Rev Respir Med. Take this drug exactly as prescribed; if a timed-release product is prescribed, take this drug on an empty stomach, 1 hour before or 2 hours after meals. 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